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Program to Accelerate Clinical Trials (PACT)

Grants to USA, Canada, and International Researchers
for Studies on Alzheimer's Therapies

Agency Type:

Foundation / Corporation

Funding Source:

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Alzheimer's Drug Discovery Foundation (ADDF)

LOI Date:


Deadline Date:

12/03/21 5:00 PM EST


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Grants to USA, Canada, and International clinicians and researchers based at nonprofits, for-profits, IHEs, and medical centers for research related to Alzheimer’s disease and dementia. Applicants must submit an LOI prior to applying. Funding is intended to support IND-enabling studies and early-phase clinical trials that test promising pharmacological interventions and devices for Alzheimer’s disease (AD) and related dementias. Both disease-modifying and symptomatic agents will be considered.

This funding opportunity prioritizes diverse drug mechanisms and models of action related to the biology of aging and other emerging therapeutic areas for dementia. 

The RFP supports:

  1. Early-stage human clinical trials:
    • Phase 0 micro- or sub-therapeutic dosing studies
    • Phase 1 trials in healthy subjects
    • Biomarker-based proof-of-concept studies (generally phase 1b or phase 2a trials) designed to assess target engagement and downstream pharmacologic effects
  2. Regulatory studies:
    • Non-GLP and GLP pharmacology and toxicology studies, pre-formulation, and GMP manufacture required for an investigational new drug (IND) and clinical trial authorization (CTA) preclinical packages. Funding is available for preparation of traditional and exploratory IND applications.
    • Long-term toxicology studies to enable longer-term dosing in phase 2 trials
    • GMP manufacture and testing of clinical-grade drug required to move into phase 2 or phase 3 trials

For clinical trial applications, if IND-enabling work is in progress, funding for clinical studies would be contingent upon an IND (or equivalent) being granted and a full review of the data package.

For information about Types of Therapy, Drug Mechanism, and Modes of Action, see the URL for Full Text.

GrantWatch ID#:

GrantWatch ID#: 172502

Estimated Size of Grant:

Average Award: Grants are up to $3,000,000 based on stage and scope of research. For studies requiring additional support, co-funding from other funding agencies or investors is encouraged. Payment structure will be negotiated and based on milestone achievements and recruitment.

Term of Contract:

Average duration: Multi-year with potential for follow-on funding.

Additional Eligibility Criteria:

Funding is open to researchers and clinicians worldwide at:
- Academic medical centers and universities or nonprofits. Industry partnerships are strongly encouraged.
- Biotechnology companies. Funding is provided through mission-related investments that require return on investment based upon scientific and/or business milestones. Existing companies and new startups are both eligible.

Anti-amyloid approaches (e.g., anti-amyloid aggregation, beta-amyloid vaccines, beta- or gamma-secretase inhibitors) and cholinesterase inhibitor proposals will not be considered

Pre-Application Information:

Due to the COVID-19 pandemic, ADDF understands there may be delays in submitting applications. It will consider an extension if delays are anticipated. Please email your scientific point person listed at the end of the RFP.

Letters of Intent and Full Proposals must be received by 5:00 PM ET on the deadline date.

Upcoming Deadlines:
- Letter of Intent: February 5, 2021
- Invited Full Proposal: April 16, 2021

- Letter of Intent: May 28, 2021
- Invited Full Proposal: July 30, 2021

- Letter of Intent: October 1, 2021
- Invited Full Proposal: December 3, 2021

Applicants are encouraged to contact program staff to discuss proposed projects and receive initial feedback.

Application instructions:

Funding Policies:

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply Online:

For scientific inquiries, please contact:
Alessio Travaglia, PhD, Assistant Director, Scientific Affairs

For application submission inquiries, please contact:
Grants and Mission-Related Investments Team

Alzheimer's Drug Discovery Foundation
57 West 57th Street, Suite 904
New York, NY 10019

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;


International country outside of the USA, Israel and Canada.

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