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Grand Challenges Explorations (GCE) - Environmental Niches of Salmonella Typhi - Round 23

Grants to USA, Canada, and International Nonprofits, For-Profits,
Agencies, and IHEs to Investigate S. Typhi Strains

Agency Type:

Foundation / Corporation

Funding Source:

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Bill and Melinda Gates Foundation - Global Grand Challenges

Deadline Date:

04/10/19 11:30 AM Pacific Daylight Time


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Grants to USA, Canada, and International nonprofits, for-profit companies, agencies, and IHEs to investigate, study, and research S. Typhi strains. Funding is intended for the examination of the environmental functions of S. Typhi and, among other goals, to have a better understanding of the impact of these niches on antibiotic resistance to the strain.

The Foundation is interesting in understanding:
- Survival of S. Typhi (Salmonella enterica ssp. enterica serovar Typhi) in the context of the soil and water microbiomes. S. Typhi survives for 3 weeks in the presence of A. castellani, but for no more than 10 days by itself. Do interactions with other organisms impact survival of S. Typhi? How do they impact transmissibility of the bacterium?
- Survival of S. Typhi within other organisms. Similar to V. cholerae, which thrives within zooplankton, does S. Typhi interact with aquatic multicellular organisms? If yes, how does this impact the transmission and epidemiology of typhoid?
- Impact of environmental niches on the development of antibiotic resistance in S. Typhi. What is the relative amount of time S. Typhi spends in the environment compared to in infected individuals? How does this impact its exposure to antibiotics, and the development of antibiotic resistance in S. Typhi strains?

The Foundation is interested in funding:
- Studies of S. Typhi in the context of soil and water microbiomes, with clear implications for survival, virulence, or antibiotic resistance.
- Examining survival of S. Typhi within or in the presence of free-living protozoans
- Examining the role of the environment (soil, water, residual antibiotics) in the development of AMR in S. Typhi
- Transcriptome analysis and mutagenesis of S. Typhi to identify genes associated with particular environmental niches.

The work proposed in an application must include a clear set of key experiments or activities that test the proposed idea in a way that could provide sufficient evidence to warrant funding. Proposals with vague descriptions or vague testing methodologies will not be funded.

All awardees will be permitted to contract for services, up to a maximum of $49,999 USD. This limit applies to funds paid by an awardee to any other organization (or an individual employed at another organization) as a subcontractor, including payments to co-PIs working at another organization. Awardees are entitled to purchase equipment, provided that the cost of each item is less than $5,000 USD. Phase I project funds may be used to cover the full direct costs of the project.

GrantWatch ID#:

GrantWatch ID#: 185424

Estimated Size of Grant:

- Awards of up to $100,000 USD are made in Phase I. Phase I awardees have one opportunity to apply for a follow-on Phase II award of up to $1,000,000 USD.

Term of Contract:

- Awarded projects start date is November 1, 2019.
- Phase I projects have a term of 18 months beginning on the project start date.
- Phase II funding has a grant term of up to two years.

Additional Eligibility Criteria:

GCE is open to both foreign and domestic organizations, including non-profit organizations, for-profit companies, international organizations, government agencies, and academic institutions.

Government units or international executive order organizations confirm that: (a) You are an entity duly organized or formed, qualified to do business, and in good standing under the laws of the jurisdiction in which you are organized or formed; (b) You are not an individual (i.e., a natural person) or a disregarded entity (e.g., a sole proprietor or sole-owner entity) under U.S. law; (c) You have the right to enter into and fully perform this Agreement; and (d) Your performance will not violate any agreement or obligation between You and any third party. You will notify the Foundation immediately if any of this changes during the term of this Agreement.

For grantees in India FCRA Registration is required.

Foreign organizations may not use more than 20% of Grant Funds for activities in the U.S., including travel to or from the U.S. This limitation does not apply to Your subgrantees or subcontractors that: (a) are independent from and not controlled by You; (b) have provided You a proposal and budget describing how the funds will be used, and You have determined that the activities and costs are reasonable; and (c) are not Your agents.

No awardee will be entitled to use funds to cover indirect costs.

The Foundation will not fund:
- Studies of only other Salmonella enterica serovars, without a focus on S. Typhi
- Clinical studies of typhoid with no environmental focus
- Solely lab-based mutagenesis studies of S. Typhi with no data to link findings to environmental samples or typhoid epidemiology.

Project funds may not be used to enroll human subjects in any research project subject to Institution Review Board (IRB) or Independent Ethics Committee (IEC) approval until such approval has been obtained for each site.

Pre-Application Information:

Proposals are due by Wednesday, April 10, 2019 11:30 a.m. U.S. Pacific Daylight Time.

Proposal review will be completed in June 2019, and notification of selections will be sent in October.

New users must create an account and submit proposals through the online portal. Applicants are encouraged to download the application form, which should be submitted either as a Microsoft Word or PDF document; no more than two pages in length.

The GCE initiative publishes topics and invites proposals two rounds a year. An applicant must submit under only one topic each round and may submit only one proposal. Submit your best idea. You may submit multiple ideas in partnership with collaborators, but an individual Principal Investigator may lead the submission of only one proposal each round. You may change your topic and edit your proposal any time before the application deadline.

Application instructions:

Selection process:


Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

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Please direct all questions by e-mail to:

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